Garmin Software: Mrna Sequence

Saturday 3 November 2012

Mrna Sequence

The information in your genes (DNA) is copied to mRNA in the form of a code defined by a sequence of nucleotides. During protein synthesis, ribosomes move along the mRNA molecule and "read" its sequence three nucleotides at a time (three nucleotides; aka a codon). Each amino acid in the protein is specified by the codons of mRNA. Since RNA is constructed from four types of nucleotides, there are 64 possible triplet sequences or codons (4x4x4). Three of these possible codons specify the termination of the polypeptide chain. They are called "stop codons". That leaves 61 codons to specify only 20 different amino acids. Therefore, most of the amino acids are represented by more than one codon.MicroRNA sequencing (miRNA-seq), a type of RNA-Seq, is the use of next-generation sequencing or massively parallel high-throughput DNA sequencing to sequence miRNAs. miRNA-seq differs from other forms of RNA-seq in that input material is often enriched for small RNAs. miRNA-seq allows researchers to examine tissue specific expression patterns, disease associations, isoforms of miRNAs, and to discover previously uncharacterized miRNAs. Evidence that dysregulated miRNAs play a role in diseases such as cancer^[1] has positioned miRNA-seq to potentially become an important tool in the future for diagnostics and prognostics as costs continue to decrease.